Diabeloop and Sequel Med Tech have announced a new partnership that will integrate Diabeloop’s DBLG2 automated insulin dosing algorithm into Sequel’s twiist Automated Insulin Delivery (AID) system.

Through the partnership, DBLG2 will be added to the twiist AID platform making it a second algorithm option for the pump, joining Tidepool Loop. The goal is to move closer to a fully closed loop insulin delivery experience by combining Diabeloop’s software with Sequel’s pump hardware, reducing the amount of day to day decision making required from users.

DBLG2 uses real time glucose data from a continuous glucose monitor (CGM) to automatically adjust insulin delivery. Setup only requires body weight and total daily insulin, and the algorithm adapts over time to each person’s glucose patterns and insulin needs. What brings it closer to a fully closed-loop system is that users may choose not to declare meals and the DBLG2 algorithm will continue to manage glucose automatically, although optimal control is achieved when meals are declared.

In December, DBLG2 received FDA clearance as a Class II Interoperable Automated Glycemic Controller (iAGC) covering people with type 1 diabetes 12 years and older. Sequel and Diabeloop expect the algorithm integration to arrive on twiist in 2027. DBLG2 got a CE marking under the EU MDR in August 2025 and is in its pre-launch phase in Europe, with a full launch planned for early 2026, including support for Kaleido and Dana-i insulin pumps.

The twiist system brings added flexibility to the integration. The pump measures the exact amount of insulin delivered with each micro dose and is cleared for people as young as six. We talked to two twiist users on the podcast to better understand their real world experience, and we also put together a site change walkthrough and a twiist app demo so readers can see how the system works in practice.

What do you think about this partnership and the addition of DBLG2 to the twiist AID system? Let us know your thoughts in the comments.

Disclaimer: Diabetech content is not medical advice—it’s for educational purposes only. Always consult with a physician before making changes to your healthcare.